2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121966
    Riparin 112356-54-4 98.00%
    Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca2+ influx and inhibiting the release of intracellular calcium ion stores.
    Riparin
  • HY-121974
    SR14150 709024-69-1 98%
    SR14150 is a partial agonist of the NOP receptor with high affinity. The biological activity of SR14150 makes it potentially useful for the development of a new generation of multi-target opioids designed to simultaneously improve analgesia and reduce side effects. The activity of SR14150 and its interaction with other opioid receptors may provide new inhibitory options for the management of chronic pain.
    SR14150
  • HY-122001
    PF-05186462 1235406-03-7 99.69%
    PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain.
    PF-05186462
  • HY-122050
    Oe-9000 675132-92-0 98%
    Oe-9000 is a compound with local anesthetic activity that inhibits voltage-gated Na+ currents in neurons, including both TTX-resistant and TTX-sensitive currents, with effects superior to those of some other local anesthetics.
    Oe-9000
  • HY-122069
    NSC177365 80261-18-3 98%
    NSC177365 (NSC 1) is a CcrM inhibitor. NSC177365 is a competitive DNA inhibitor and disrupts DNA binding. NSC177365 has antibacterial activity, with IC50s of 2.3 and 14.6 μM for C. crescentus and M. lincolnii respectively. NSC177365 reverses several neurodegenerative disorders and serve as an anticancer agent.
    NSC177365
  • HY-122070
    Tirilazad mesylate 110101-67-2 98%
    Tirilazad mesylate (U 74006F) is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research.
    Tirilazad mesylate
  • HY-122080
    Memoquin 616885-87-1 98%
    Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).
    Memoquin
  • HY-122086
    Prifinium bromide 4630-95-9 98%
    Prifinium bromide is antimuscarinic agent with antispasmodic, antiemetic effect.
    Prifinium bromide
  • HY-122152
    Spiclomazine hydrochloride 27007-85-8 98%
    Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis.
    Spiclomazine hydrochloride
  • HY-122216
    LY 88329 78693-86-4 98%
    LY 88329 is a potent narcotic antagonist.
    LY 88329
  • HY-122231
    MRS3558 793695-40-6 98%
    MRS3558 is a potent and selective A3AR agonist, with Ki values of 0.6 nM for humans and 0.9 nM for rats, making it suitable for research in the fields of neuropathic pain and anesthesia.
    MRS3558
  • HY-122232
    SW083688 422281-45-6 98%
    SW083688 is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2) inhibitor (IC50 values = 1.3 umol/L).
    SW083688
  • HY-122271
    Safrazine hydrochloride 7296-30-2 98%
    Safrazine Hydrochloride is a monoamine oxidase inhibitor with irreversible activity. It is mainly used to inhibit depression and other mood disorders. As a compound, its mechanism is to increase the level of monoamine neurotransmitters in the body by blocking the activity of monoamine oxidase, thereby improving mood and psychological state.
    Safrazine hydrochloride
  • HY-122278
    Melevodopa 7101-51-1
    Melevodopa is an effervescent levodopa (HY-N0304) prodrug. Levodopa is an orally active metabolic precursor of neurotransmitters dopamine and has anti-allodynic effects and the potential for Parkinson's disease.
    Melevodopa
  • HY-122294
    Rociverine 53716-44-2 98%
    Rociverine is an anticholinergic compound with smooth muscle relaxant activity. Rociverine showed different binding modes in five cloned muscarinic receptors. The cis stereoisomer of Rociverine showed a higher affinity change compared to the trans stereoisomer. The (1R,2R) configuration of Rociverine showed significantly higher affinity, even up to 240 times. The (1S,2S) configuration of Rociverine is very important for binding selectivity.
    Rociverine
  • HY-122300
    R-(-)-Oxaprotiline hydrochloride 76496-69-0 98%
    R-(-)-Oxaprotiline (Levoprotiline) hydrochloride is the R-enantiomer of Oxaprotiline. Oxaprotiline is a tetracyclic antidepressant agent.
    R-(-)-Oxaprotiline hydrochloride
  • HY-122303
    4-hydroxy DiPT hydrochloride 63065-90-7 98%
    4-hydroxy DiPT hydrochloride is an 5-HT2A agonist that induces the head-twitch response (HTR) in mice, indicating psychoactivity.
    4-hydroxy DiPT hydrochloride
  • HY-122347
    Orvepitant 579475-18-6 98%
    Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.
    Orvepitant
  • HY-122367
    Neoxaline 909900-78-3 98%
    Neoxaline is an alkaloid produced by Aspergillus japonicus. Neoxaline does not possess antimicrobial activities, but weakly stimulates the central nervous system.
    Neoxaline
  • HY-12236B
    (R)-SKF-81297 hydrobromide 253446-15-0 98%
    (R)-SKF-81297 hydrobromide is the R-enantiomer of SKF-81297 (HY-12236A). SKF-81297 is a selective agonist for dopamine D1 receptor.
    (R)-SKF-81297 hydrobromide
Cat. No. Product Name / Synonyms Application Reactivity